paper in Frontiers
Differentiated memory and scientific cognition in AI research agents
Cuadros DF, Maiga A-A, Thatham S, Ortiz A, Powers-Fletcher M and Tang M (2026) Differentiated memory and scientific cognition in AI research agents. Front. Big Data 9:1916523. doi: 10.3389/fdata.2026.1916523
AI research agents increasingly support ideation, literature search, coding, experimental execution, analysis, and manuscript drafting across the scientific workflow. This progress advances automated discovery, but workflow automation is not scientific cognition. Scientific reasoning is cumulative and path-dependent: it depends on what a researcher has written, read, learned from critique, absorbed through experience, and used as habitual standards for judging novelty, rigor, feasibility, and significance. We propose Mnemo as a framework for modeling scientific cognition in AI research agents. First, scientific cognition may require differentiated memory, organized into distinct spaces for authored work, external reference, critique, experience, and judgment. Second, provenance should be treated not as passive metadata but as memory routing, because source origin helps determine cognitive function in reasoning. Third, new ideas may be better modeled as controlled collisions across memory spaces, filtered by judgment, rejection, and epistemic calibration, than as generic recombination from model priors. Mnemo motivates a research agenda for AI in science centered on routing fidelity, critique use, judgment alignment, rejection quality, and epistemic calibration.






Digital health innovations (DHI) present important opportunities to improve individual health outcomes and community well-being; however, they are typically developed by private sector innovators who prioritize the novelty of innovation and data-driven value creation over achieving health equity. Resultantly, Black lived experiences and perceptions of digital innovations are regularly overlooked in digital innovation development. This exclusion, exacerbated by the digital divide and place-based structural barriers, perpetuates racialized health inequities and widespread institutional mistrust among Black communities. In our study, we address these complex challenges through the question, “What are the digital data governance preferences of Black communities that should inform DHI development”? This question is the first of a broader study that seeks to generate a gamified DHI using “digital twinning” (3D, GIS based city modeling with virtual reality) for health outcomes improvement by integrating these community-driven data governance policies and fostering institution trust. We use mixed methods consisting of a longitudinal survey, listening sessions and focus groups, demonstration sessions, co-design hubs, and user-contributed Ecological Momentary Assessment (EMA) data to answer our questions and to test community perceptions of and experiences using the gamified DHI. By the time of this presentation, we anticipate having findings from the first survey, listening sessions, and focus groups along with preliminary community-driven data governance policies and a draft game design architecture. This interdisciplinary study represents a novel opportunity to not only improve health outcomes within marginalized communities, but also to repair institutional mistrust and foster digital literacy and agency through the co-design of digital data governance policies. 






